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Erik Hedrick Selected Research

1,1- bis(3'- indolyl)- 1- (4- hydroxyphenyl)methane

11/2019Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma.
8/2019Potent inhibition of breast cancer by bis-indole-derived nuclear receptor 4A1 (NR4A1) antagonists.
1/2017The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists.
5/2016Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS).
5/2016NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration.
10/2014Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells.

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Erik Hedrick Research Topics

Disease

15Neoplasms (Cancer)
10/2021 - 02/2014
6Breast Neoplasms (Breast Cancer)
08/2019 - 10/2015
5Pancreatic Neoplasms (Pancreatic Cancer)
10/2021 - 10/2014
4Rhabdomyosarcoma
11/2019 - 09/2015
3Neoplasm Metastasis (Metastasis)
01/2018 - 05/2016
2Colonic Neoplasms (Colon Cancer)
01/2017 - 10/2014
1Alveolar Rhabdomyosarcoma
12/2018
1Lung Neoplasms (Lung Cancer)
12/2018
1Inflammation (Inflammations)
01/2018
1Adenocarcinoma of Lung
01/2018
1Triple Negative Breast Neoplasms
09/2017
1Oncogene Addiction
04/2016
1Renal Cell Carcinoma (Grawitz Tumor)
01/2015

Drug/Important Bio-Agent (IBA)

8Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
10/2021 - 10/2014
6Proteins (Proteins, Gene)FDA Link
10/2021 - 04/2016
61,1- bis(3'- indolyl)- 1- (4- hydroxyphenyl)methaneIBA
11/2019 - 10/2014
6Pharmaceutical PreparationsIBA
01/2018 - 02/2014
5Sp Transcription FactorsIBA
10/2021 - 09/2015
5Reactive Oxygen Species (Oxygen Radicals)IBA
11/2019 - 09/2015
4Orphan Nuclear ReceptorsIBA
10/2021 - 02/2014
4LigandsIBA
12/2018 - 10/2014
2Transcription Factors (Transcription Factor)IBA
10/2021 - 04/2016
2CytokinesIBA
11/2019 - 12/2018
2Annexin A5IBA
08/2019 - 05/2016
2Proteasome Endopeptidase Complex (Proteasome)IBA
12/2018 - 09/2017
2Transforming Growth Factors (Transforming Growth Factor)IBA
09/2017 - 05/2016
2Glutathione (Reduced Glutathione)IBA
08/2017 - 01/2017
2IntegrinsIBA
01/2017 - 05/2016
2Member 1 Group A Nuclear Receptor Subfamily 4IBA
05/2016 - 01/2015
2SurvivinIBA
10/2015 - 10/2014
1celastrolIBA
10/2021
1TriterpenesIBA
10/2021
1indoleIBA
08/2019
1JNK Mitogen-Activated Protein KinasesIBA
12/2018
1RNA (Ribonucleic Acid)IBA
12/2018
1interleukin-24 (ST16)IBA
12/2018
1pyrazolanthroneIBA
12/2018
1Long Noncoding RNAIBA
01/2018
1CurcuminIBA
01/2018
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
01/2018
1Metformin (Glucophage)FDA LinkGeneric
01/2018
1Mitogen-Activated Protein Kinase 14IBA
09/2017
1piperlongumineIBA
08/2017
1AntioxidantsIBA
08/2017
1Biological ProductsIBA
08/2017
1Penfluridol (Semap)IBA
01/2017
1Fibronectins (Fibronectin)IBA
01/2017
1Messenger RNA (mRNA)IBA
01/2017
1STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
12/2016
1benzyl isothiocyanateIBA
12/2016
1Hydroxyl RadicalIBA
05/2016
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
05/2016
1ThioredoxinsIBA
10/2015
1Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA
10/2015
1ErbB Receptors (EGF Receptor)IBA
10/2015
1Histone Deacetylases (Histone Deacetylase)IBA
09/2015
1Histone Deacetylase InhibitorsIBA
09/2015
1PanobinostatIBA
09/2015
1VorinostatFDA Link
09/2015
1OligonucleotidesIBA
01/2015
1Antineoplastic Agents (Antineoplastics)IBA
10/2014
1LuciferasesIBA
10/2014
1TOR Serine-Threonine KinasesIBA
10/2014
13,3'-diindolylmethane (diindolylmethane)IBA
10/2014

Therapy/Procedure

4Drug Therapy (Chemotherapy)
04/2016 - 02/2014
2Therapeutics
12/2018 - 01/2017